education

  • Honors BA. Biochemistry & Biophysics. Oregon State University Honors College, 2006. Summa Cum Laude. Thesis: Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations. Adviser:Andrew Buermeyer, PhD.

  • PhD, Toxicology. Oregon State University, 2013. Dissertation: Discovery and Mechanism of Action of Anti-Cancer Compounds Targeting the Aryl Hydrocarbon Receptor. Adviser: Siva. K. Kolluri, PhD. 

  • Postdoctoral Researcher, Oregon State University. 2013-2015. Cancer Biology Laboratory, Department of Environmental & Molecular Toxicology.  Adviser: Siva. K. Kolluri, PhD.

  • MD.  Albert Einstein College of Medicine of Yeshiva University. 2015-2019. Elected to Alpha Omega Alpha Honor Medical Society.

  • Internship, Department of Orthopaedic Surgery, UC Davis Medical Center. 2019-2020.

  • Residency, Orthopaedic Surgery. Department of Orthopaedic Surgery, UC Davis Medical Center. 2020-2025 ( PGY3 Dedicated Research Year).

PuBLICATIONS

Kolluri SK, Zhu X, Zhou X, Lin B, Chen Y, Sun K, Tian X, Town J, Cao X, Lin F, Zhai D, Kitada S, Luciano F, O'Donnell E, Cao Y, He F, Lin J, Reed JC, Satterthwait AC, Zhang XK. A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell. 2008 Oct 7;14(4):285-98

Bisson, W. H., Koch, D. C., O'Donnell, E. F., Khalil, S. M., Kerkvliet, N. I., Tanguay, R. L., Abagyan, R., and Kolluri, S. K., Modeling of the Aryl Hydrocarbon Receptor (AhR) Ligand Binding Domain and Its Utility in Virtual Ligand Screening to Predict New AhR Ligands. Journal of Medicinal Chemistry 52 (18), 5635-5641, 2009.

O'Donnell E.F., Saili KS, Koch DC, Kopparapu PR, Farrer D, Bisson WH, Mathew LK, Sengupta S, Kerkvliet N.I., Tanguay RL, Kolluri SK. The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One. 2010 Oct 1;5(10):e13128.

O'Donnell E.F., Kopparapu PR, Koch DC, Jang HS, Phillips JL, Tanguay RL, Kerkvliet NI, Kumar SK. The Aryl Hydrocarbon Receptor Mediates Leflunomide-Induced Growth Inhibition of Melanoma Cells. PLoS One. 2012;7(7):e40926.

O’Donnell, EF; Koch, DC; Bisson, WH; Jang, HS; Kolluri, SK. The Aryl Hydrocarbon Receptor Mediates Raloxifene induced Apoptosis in Estrogen Receptor Negative Hepatoma and Breast Cancer Cells. Cell Death & Disease 2014 Jan 30;5:e1038. doi:10.1038/cddis.2013.549.

  Punj, S; Kopparapu, PK; Jang, HS; Phillips, JL; Pennington, J; Rohlman, D; O'Donnell, EF; Iversen, PL; Kolluri, SK; Kerkvliet, NI; A new class of AhR ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One Feb 19;9(2):e88726. doi: 10.1371/journal.pone.0088726.

Koch DC, Jang HS, O'Donnell EF, Punj S, Kopparapu PR, Bisson WH, Kerkvliet NI, Kolluri SK. Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1. Oncogene. 2015 Apr 13. doi: 10.1038/onc.2015.55. [Epub ahead of print] PubMed PMID: 25867062.